In 2012, the Mets celebrated their 50th anniversary. A season highlighted by a 20-win performance from pitcher R. A. Dickey started out well, but diminished in the second half. The team sported a 74-88 won-lost record.
The Mets began their golden anniversary with 13 wins in 23 games in April. The team started the season by winning its first four games and seven of its first ten. They concluded a home stand with a three-game sweep of the Marlins and followed up with two wins in a weekend series at Colorado. The Mets ended the month in third place, one and one-half games behind the division-leading Nationals in the National League East.
In May, the Mets had 15 wins and a .536 percentage for the month. They began a five-game winning streak with a 4-3 victory over the Diamondbacks at Citi Field on May 5. The team recorded one win in each of its next four series before taking two of three games in a series at Pittsburgh. The Mets ended the month with four victories in seven games against the Padres and Phillies at Citi Field. They stood third in the division, one and one-half games in back of front-running Washington.
The Mets had their third straight winning month in June. They recorded 15 victories in 28 games played. On June 1 at Citi Field, Johan Santana pitched the team's first no-hitter in its history for an 8-0 Mets triumph over the Cardinals. They followed up with two more wins over St. Louis, but lost six of their next seven games. The Mets swept three-game interleague series at Tampa Bay and at home against the Orioles between June 12 and June 20. The team closed out the month with four consecutive wins at Chicago and Los Angeles. The Mets were second in the N. L. East, two and one-half games behind the Nationals.
The Mets' season took a nosedive in July. The team had only seven wins and 18 losses during the month. After splitting six games with the Phillies and Cubs at Citi Field, the Mets returned from the All-Star Break with five straight defeats at Atlanta and Washington. On a home stand from July 20 to July 25, they dropped six in a row against the Dodgers and Nationals. The Mets split a four-game series at Arizona from July 26 to July 29. At San Francisco on July 30, they came away with an 8-7 victory over the Giants in 10 innings. The Mets were twelve games behind the division-leading Nationals and third in the N. L. East standings at month's end.
In August, the Mets had another losing month. They went 12-16 for a .429 winning percentage. The team recorded 2-1 and 9-1 victories at San Francisco on August 1 and August 2, respectively, before dropping two of three at San Diego. They lost four of six on both a home stand and an ensuing road trip to Cincinnati and Washington. The Mets began a four-game winning streak with a 3-1 triumph over the Astros at Citi Field on August 25. At Miami on August 31, they ended the month with a 3-0 win over the Marlins. The Mets were fourth in the division and eighteen and one-half games behind first-place Washington.
Over the final thirty games of the season, the Mets won 12 and lost 18. They started September with a pair of victories at Miami, but dropped two of three at St. Louis to follow up. The team lost all six games on an ensuing home stand before a 7-3 win over the Brewers at Milwaukee on September 14. Between September 21 and September 27, the Mets won six of seven games against the Marlins and Pirates at Citi Field. They finished the month with two losses in a three-game series at Atlanta. On October 3, the team ended the season with a 4-2 win over the Marlins at Miami. The Mets wound up fourth in the N. L. East, twenty-four games behind the division-champion Nationals.
- Dickey was named the National League Cy Young winner.